Background: Seleno-proteins, Iodothyronine 5’ dehydronases (DIO) affect the function of thyroid gland. The expression of receptors of DIOs are affected by sex hormones (Oestradiol and Testosterone). The objective of this research therefore was to study differential effect of these hormones in boys and girls (Tick-Phenomenon). Methods: Fifty HIV 1 positive, treatment Naïve children, were enrolled for the study. Half 25 were given fixed dose of 50 µgm yeast selenium while the matched 25 were on control. Weight was taken at 0, 3 and 6 months. Results: Children on selenium had weight gain of 2.5Kg at six months. The weight for age Z score increased above -2SDs cut off point at six months among children on selenium, in all age categories {, 3-5 years 1.20±2.45, 6-8years 0.19±0.880, 9-15 years 0.97±1.22}. In the matched Controls there was a decrease in WAZ in all the age categories to below -2SDs at six months {, 3-5 years -2.218±1.46, 6-8 years -2.95.±3.10, 9-15 -2.30±1.240}. There was a significant WAZ difference between controls and selenium group at six months {F (5,12)==5.758, P=0.006}. Female children on selenium initially had a decrease and then sharp increase in WAZ (Tick Phenomenon), compared to the males who had a gradual increase in WAZ. Conclusion: It can be concluded that intake of yeast Selenium led to significant increase in weight for age Z score at six months and that there is gender related differences in weight change between HIV 1 positive female and male children on test and controls, the females showing Tick phenomenon.
| Published in | Journal of Health and Environmental Research (Volume 7, Issue 3) |
| DOI | 10.11648/j.jher.20210703.13 |
| Page(s) | 134-138 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Selenium, Children, Hormones, Pre-puberty, Weight Change, Children
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APA Style
Otieno Samwel Boaz, Were Fred, Kabiru Ephantus Wanjoi. (2021). Effect of Selenium on Weight Change of HIV 1 Positive Pre-puberty Treatment Naive Children: Tick Phenomenon. Journal of Health and Environmental Research, 7(3), 134-138. https://doi.org/10.11648/j.jher.20210703.13
ACS Style
Otieno Samwel Boaz; Were Fred; Kabiru Ephantus Wanjoi. Effect of Selenium on Weight Change of HIV 1 Positive Pre-puberty Treatment Naive Children: Tick Phenomenon. J. Health Environ. Res. 2021, 7(3), 134-138. doi: 10.11648/j.jher.20210703.13
AMA Style
Otieno Samwel Boaz, Were Fred, Kabiru Ephantus Wanjoi. Effect of Selenium on Weight Change of HIV 1 Positive Pre-puberty Treatment Naive Children: Tick Phenomenon. J Health Environ Res. 2021;7(3):134-138. doi: 10.11648/j.jher.20210703.13
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Download@article{10.11648/j.jher.20210703.13,
author = {Otieno Samwel Boaz and Were Fred and Kabiru Ephantus Wanjoi},
title = {Effect of Selenium on Weight Change of HIV 1 Positive Pre-puberty Treatment Naive Children: Tick Phenomenon},
journal = {Journal of Health and Environmental Research},
volume = {7},
number = {3},
pages = {134-138},
doi = {10.11648/j.jher.20210703.13},
url = {https://doi.org/10.11648/j.jher.20210703.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jher.20210703.13},
abstract = {Background: Seleno-proteins, Iodothyronine 5’ dehydronases (DIO) affect the function of thyroid gland. The expression of receptors of DIOs are affected by sex hormones (Oestradiol and Testosterone). The objective of this research therefore was to study differential effect of these hormones in boys and girls (Tick-Phenomenon). Methods: Fifty HIV 1 positive, treatment Naïve children, were enrolled for the study. Half 25 were given fixed dose of 50 µgm yeast selenium while the matched 25 were on control. Weight was taken at 0, 3 and 6 months. Results: Children on selenium had weight gain of 2.5Kg at six months. The weight for age Z score increased above -2SDs cut off point at six months among children on selenium, in all age categories {, 3-5 years 1.20±2.45, 6-8years 0.19±0.880, 9-15 years 0.97±1.22}. In the matched Controls there was a decrease in WAZ in all the age categories to below -2SDs at six months {, 3-5 years -2.218±1.46, 6-8 years -2.95.±3.10, 9-15 -2.30±1.240}. There was a significant WAZ difference between controls and selenium group at six months {F (5,12)==5.758, P=0.006}. Female children on selenium initially had a decrease and then sharp increase in WAZ (Tick Phenomenon), compared to the males who had a gradual increase in WAZ. Conclusion: It can be concluded that intake of yeast Selenium led to significant increase in weight for age Z score at six months and that there is gender related differences in weight change between HIV 1 positive female and male children on test and controls, the females showing Tick phenomenon.},
year = {2021}
}
TY - JOUR
T1 - Effect of Selenium on Weight Change of HIV 1 Positive Pre-puberty Treatment Naive Children: Tick Phenomenon
AU - Otieno Samwel Boaz
AU - Were Fred
AU - Kabiru Ephantus Wanjoi
Y1 - 2021/07/23
PY - 2021
N1 - https://doi.org/10.11648/j.jher.20210703.13
DO - 10.11648/j.jher.20210703.13
T2 - Journal of Health and Environmental Research
JF - Journal of Health and Environmental Research
JO - Journal of Health and Environmental Research
SP - 134
EP - 138
PB - Science Publishing Group
SN - 2472-3592
UR - https://doi.org/10.11648/j.jher.20210703.13
AB - Background: Seleno-proteins, Iodothyronine 5’ dehydronases (DIO) affect the function of thyroid gland. The expression of receptors of DIOs are affected by sex hormones (Oestradiol and Testosterone). The objective of this research therefore was to study differential effect of these hormones in boys and girls (Tick-Phenomenon). Methods: Fifty HIV 1 positive, treatment Naïve children, were enrolled for the study. Half 25 were given fixed dose of 50 µgm yeast selenium while the matched 25 were on control. Weight was taken at 0, 3 and 6 months. Results: Children on selenium had weight gain of 2.5Kg at six months. The weight for age Z score increased above -2SDs cut off point at six months among children on selenium, in all age categories {, 3-5 years 1.20±2.45, 6-8years 0.19±0.880, 9-15 years 0.97±1.22}. In the matched Controls there was a decrease in WAZ in all the age categories to below -2SDs at six months {, 3-5 years -2.218±1.46, 6-8 years -2.95.±3.10, 9-15 -2.30±1.240}. There was a significant WAZ difference between controls and selenium group at six months {F (5,12)==5.758, P=0.006}. Female children on selenium initially had a decrease and then sharp increase in WAZ (Tick Phenomenon), compared to the males who had a gradual increase in WAZ. Conclusion: It can be concluded that intake of yeast Selenium led to significant increase in weight for age Z score at six months and that there is gender related differences in weight change between HIV 1 positive female and male children on test and controls, the females showing Tick phenomenon.
VL - 7
IS - 3
ER -
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